Survival Analysis of Newborns with Low Birth Weight (Very and Extremely Low) in Kyrgyzstan
DOI:
https://doi.org/10.6000/Keywords:
Perinatal mortality, premature birth, antenatal care, neonatal intensive care, organisation of logistics, gastrointestinal tractAbstract
Purpose: The increase in the number of premature births in the Kyrgyz Republic was accompanied by the
growth of the proportion of newborns with very low (VLBW) and extremely low birth weight (ELBW), which required a
systematic analysis of the survival. The study aimed to determine the dynamics of survival among newborns in these
groups for 2019-2024, accounting for regional differences.
Material and Methods: Kaplan-Meier curves and the log-rank test were used to assess statistical significance. Data,
including medical records, reports from perinatal centres, and official statistics from the National Statistical Committee of
the Kyrgyz Republic, were collected from all regions of the country, with an emphasis on regional differences in neonatal
care infrastructure.
Results: The survival of newborns weighing 1,000 to 1,499 grams increased from 23.4% to 51.8%, accompanied by a
reduction in early neonatal mortality from 48% to 26%. Among children weighing less than 1,000 grams, survival
increased from 2.2% to 8.6%, at remained low. It was established that the most pronounced improvement was observed
in the southern regions of the country, whereas in the northern and mountainous areas, the lag remained. The main
factors driving positive dynamics were the expansion of antenatal care, the equipping of hospitals with intensive care
equipment, and improvements in staff qualifications.
Conclusion: The practical significance of the study lies in the justification for further development of neonatal care
infrastructure to reduce infant mortality and balance regional differences in Kyrgyzstan.
References
National Statistical Committee of the Kyrgyz Republic. Infant
mortality. Available from: https://stat.gov.kg/ru/opendata/
category/143/.
[2] Ramaswamy V, Abiramalatha T, Bandyopadhyay T, Shaik N,
Bandiya P, Nanda D, et al. ELBW and ELGAN outcomes in
developing nations: Systematic review and meta-analysis.
PLoS One 2021; 16(8): e0255352.
https://doi.org/10.1371/journal.pone.0255352
[3] Michaelis I, Krägeloh-Mann I, Mazinu M, Jordaan E. Growth
of a cohort of very low birth weight and preterm infants born
at a single tertiary health care center in South Africa. Front
Pediatr 2023; 10: 1075645.
https://doi.org/10.3389/fped.2022.1075645
[4] Hussain N, Adil M. Risk factors associated with very low birth
weight: A systematic review and meta-analysis. Int J Innov
Sci Technol 2022; 4(3): 891-8.
https://doi.org/10.33411/ijist/2022040319
[5] UNICEF. UNICEF in Kyrgyzstan 2023. Available from:
https://www.unicef.org/kyrgyzstan
[6] Baltazar-Braganza K, Velasco-Aro S. Efficacy and safety of
prophylactic antifungal agents in preventing invasive fungal
infection and mortality among infants weighing less than
1500 grams: A meta-analysis. Acta Med Philipp 2022; 56(9):
53-66.
https://doi.org/10.47895/amp.v56i9.5398
[7] Qurashi A. Gender differences in survival rates among
extreme low birth weight infants: Insight from a 16-year,
single-centre study. J Neonatal Perinatal Med 2025; 18(2):
137-41.
https://doi.org/10.1177/19345798241310150
[8] Yang M, Chang Y, Ahn S, Sung S, Park W. Neonatal
intensive care quality level-dependent variations in the
survival rate of infants with a birth weight of 500 g or less in
Korea: A nationwide cohort study. Neonatology 2022; 120(1):
49-56.
https://doi.org/10.1159/000527613
[9] Deshmukh M, Patole S. Prophylactic probiotic
supplementation for preterm neonates: A systematic review
and meta-analysis of nonrandomized studies. Adv Nutr 2021;
12(4): 1411-23.
https://doi.org/10.1093/advances/nmaa164
[10] World Health Organization. WHO recommendations for care
of the preterm or low-birth-weight infant 2022. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK586708/
[11] Government of the Kyrgyz Republic. Resolution No. 748 "On
Approval of the Regulation on the Procedure for Registration
of Civil Status Acts in the Kyrgyz Republic" 2003. Available
from: https://cbd.minjust.gov.kg/7-9660/edition/323290/ru
[12] Jing J, Dai Y, Li Y, Zhou P, Li X, Mei J, et al. Single-course
antenatal corticosteroids is related to faster growth in verylow-birth-weight infants. BMC Pregnancy Childbirth 2021;
21: 50.
https://doi.org/10.1186/s12884-020-03510-w
[13] Khreisat BM, Donayeva A, Jaafar ZAA, Shaimbetov Zh,
Abdelazim IA, Sarkulova Z, et al. The acceptable
haemoglobin's drop after uncomplicated caesarean sections.
J Mother Child 2024; 28(1): 129-35.
https://doi.org/10.34763/jmotherandchild.20242801.d-24-
00050
[14] Biedermann R, Schleußner E, Lauten A, Heimann Y,
Lehmann T, Proquitté H, et al. Inadequate timing limits the
benefit of antenatal corticosteroids on neonatal outcome:
Retrospective analysis of a high-risk cohort of preterm infants
in a tertiary center in Germany. Geburtshilfe Frauenheilkd
2022; 82(3): 317-25.
https://doi.org/10.1055/a-1608-1138
[15] Kasian S, Loboda A, Smiyan O, Popov S, Petrashenko V,
Zahorodnii M, et al. The lead content in biological media of
term infants with hypoxic-ischemic CNS. Bangladesh J Med
Sci 2021; 20(2): 330-3.
https://doi.org/10.3329/bjms.v20i2.51543
[16] Lee R, Williams E, Dassios T, Greenough A. Influence of
antenatal corticosteroids and sex on the mortality and
morbidity of extremely prematurely born infants. J Matern
Fetal Neonatal Med 2021; 35(25): 8062-5.
https://doi.org/10.1080/14767058.2021.1940941
[17] Kavurt S, Baş A, İşleyen F, Tosun M, Işık D, Demirel N.
Short-term outcomes of extremely low birth weight infants in
a tertiary neonatal intensive care unit in Türkiye. Turk J
Pediatr 2023; 65(3): 377-86.
https://doi.org/10.24953/turkjped.2022.1021
[18] Chung S, Kim C, Choi Y, Lee M, Lim J, Lee B, et al. Mortality
of very low birth weight infants by neonatal intensive care
unit workload and regional group status. Clin Exp Pediatr
2024; 67(11): 619-27.
https://doi.org/10.3345/cep.2023.01613
[19] Chanie E, Engedaw D, Eyayu T, Admasu F, Amera E,
Azanaw K, et al. Escalating the limit of median survival time
and predictors of mortality among preterm neonates in
Northwest Ethiopia, 2021: A 1-year prospective follow-up
study. BMJ Open 2022; 12: e061385.
https://doi.org/10.1136/bmjopen-2022-061385
[20] Lisiecka MZ. Side effects and hypersensitivity reactions to
corticosteroids. Med Perspekt 2024; 29(1): 95-104.
https://doi.org/10.26641/2307-0404.2024.2.307587
[21] Ali A, Naseem H, Allahuddin Z, Yasin R, Azhar M, Hanif S, et
al. Effectiveness of regionalization of perinatal care and
facility-based interventions: A systematic review.
Neonatology 2024; 122(1): 245-61.
https://doi.org/10.1159/000541384
[22] Solano SC, Guao MT, Tirado AP, Saavedra MP, Pérez AD.
Multifactorial model for the prediction of amniotic fluid index
and its correlation with maternal and fetal complications in
pregnant women in Colombia. Gac Med Caracas 2024; 132:
S101-14.
https://doi.org/10.47307/GMC.2024.132.s1.15
[23] Meloni P, Izzo S, De Intinis C, Simari T, Motzo M, Picazzo R,
et al. Rare complication post-conization for cervical
dysplasia: Rectovaginal fistula. Clin Pract 2023; 13(5): 1025-
34.
https://doi.org/10.3390/clinpract13050091
[24] Akhter M, Pervez M, Sultana S, Haque M, Kadir A, Bhuiyan
M, et al. Factors affecting the outcome of neonatal transport
in a tertiary care hospital in Bangladesh. Int J Contemp
Pediatr 2025; 12(3): 356-61.
https://doi.org/10.18203/2349-3291.ijcp20250395
[25] Cerovac A, Nevačinović E, Habek D, Laganà A, Chiantera V,
Naem A, et al. Capabilities of perinatal healthcare institutions
in primary and tertiary care of low birth weight infants in the
170 International Journal of Child Health and Nutrition, 2025, Vol. 15, No. 3 Tabyshova et al.
Federation of Bosnia and Herzegovina: A cross-sectional
multicentric study. Ann Med Surg 2024; 86(2): 768-72.
https://doi.org/10.1097/MS9.0000000000001634
[26] Bellini C, Gente M, Battaglini M, Ammattatelli R, Ramenghi L.
Neonatal transport study underlines the need to improve the
regionalisation of perinatal care in Italy. Acta Paediatr 2022;
112(2): 252-3.
https://doi.org/10.1111/apa.16599
[27] Dhahir A, Alalaf S. Maternal and neonatal characteristics that
influence early neonatal deaths in a maternity teaching
hospital. Zanco J Med Sci 2022; 26(2): 96-107.
https://doi.org/10.15218/zjms.2022.011
[28] Dafroyati Y, Widyastuty R, Kristina RH. Health belief model
analysis on the maternal through antenatal care as an effort
to prevent mortality. Gac Med Caracas 2024; 132(3): 656-64.
https://doi.org/10.47307/GMC.2024.132.3.8
[29] Chen Y, Cheng T, Zhu H, Xia S. Effects of continuous quality
improvement on complication rate and treatment outcome of
extremely premature infants. Altern Ther Health Med 2025;
31(1): 227-33. Available from:
https://pubmed.ncbi.nlm.nih.gov/38607199/
[30] Lisiecka MZ. Polyethylene glycol and immunology: Aspects
of allergic reactions and their mechanisms, as well as ways
to prevent them in clinical practice. Immun Res 2024; 72(4):
675-82.
https://doi.org/10.1007/s12026-024-09473-w
[31] Inoue S, Muta Y, Yuta T, Kawaguchi K, Odaka A. Impact of
surgical treatment on neonatal management in extremely low
birth weight infants: Single-center retrospective study. Glob
Pediatr 2025; 11: 100240.
https://doi.org/10.1016/j.gpeds.2024.100240
[32] Cattolico A, Sergio F, Boemio A, Catani O, Noviello M, De
Girolamo CI, et al. Preliminary anatomical and surgical
assessment of combined percutaneous resection and
proximal medial gastrocnemius release vs historical controls
in treating Haglund syndrome: A mixed prospectiveretrospective study. Foot Ankle Orthop 2025; 10(3):
24730114251372601.
https://doi.org/10.1177/24730114251372601
[33] Affronti A, Ruel M. Emergency surgery for iatrogenic injuries
attributable to percutaneous coronary interventions: When
planning and time matter. J Am Heart Assoc 2019; 8(1):
e011525.
https://doi.org/10.1161/JAHA.118.011525
[34] Barnette B, Schumacher B, Armenta R, Wynn J, Richardson
A, Bradley J, et al. Contribution of concurrent comorbidities to
sepsis-related mortality in preterm infants ≤32 weeks of
gestation at an academic neonatal intensive care network.
Am J Perinatol 2021; 41(2): 134-42.
https://doi.org/10.1055/a-1675-2899
[35] Dai Z, Zhong X, Chen Q, Chen Y, Pan S, Ye H, et al.
Identification of neonatal factors predicting pre-discharge
mortality in extremely preterm or extremely low birth weight
infants: A historical cohort study. Children 2024; 11(12):
1453.
https://doi.org/10.3390/children11121453
[36] Turmukhambetov AZh, Buketova GK, Gafurov NM,
Adekenov SM. Chrysartemin A and Canin from Achillea
nobilis. Chem Nat Compd 1999; 35(1): 102.
https://doi.org/10.1007/BF02238225
[37] Adekenov SM, Kupriyanov AN, Gafurov NM, Kurmanova
RSh. Sesquiterpene lactones of Artemisia saissanica. Chem
Nat Compd 1990; 26(6): 716-17. Available from:
https://link.springer.com/article/10.1007/BF00630095
[38] Poladych I. Vitamin D deficiency as a trigger of inflammation
and preterm birth. Bull Med Biol Res 2025; 7(3): 73-9.
https://doi.org/10.63341/bmbr/3.2025.73
[39] Zakharova A, Govsieiev D. Modern approach to monitoring
and preventing osteoporosis development in breast milk
donors. Bull Med Biol Res 2025; 7(2): 8-20.
https://doi.org/10.63341/bmbr/2.2025.08
[40] Shuliha-Nedaikhliebova OV, Kovalova AV, Kuzyk PV,
Salamakha OO, Zokhniuk NM, Shul OM, et al. Idiopathic
granulomatous mastitis: A clinical case and a review of the
literature. Zaporozhye Med J 2022; 24(2): 254-62.
https://doi.org/10.14739/2310-1210.2022.2.233123
[41] Molle M, Uderzo S, D’Addato C, Gesuete FP, Nicoletti GF,
Ferraro GA. Is quality of life after breast reduction influenced
by different surgery techniques? A prospective study.
Aesthetic Plast Surg 2024; 48(23): 4973-8.
https://doi.org/10.1007/s00266-024-04050-w
[42] Affronti A, Ruel M, Gaudino MFL. Multiarterial coronary artery
bypass grafting: Is the radial artery fulfilling the unkept
promise of the right internal thoracic artery? Curr Opin
Cardiol 2019; 34(6): 628-36.
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